ITGA10

Across TCGA pan-cancer cohorts, ITGA10 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ITGA10’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ITGA10 RNA is repressed in tumor relative to normal tissue. In most cancer types ITGA10 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and BLCA are the cancer types where ITGA10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITGA10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−1.804	<.001	8	view →
LUAD	Male	All	−1.010	<.001	8	view →
BLCA	Male	All	−0.810	<.001	7	view →
KIRP	All	All	−0.604	<.001	7	view →
LIHC	Female	All	+0.310	<.001	7	view →
KICH	Female	All	−1.500	<.001	6	view →
BRCA	Female	All	−0.867	<.001	6	view →
READ	All	II,III,IV	+0.322	.018	5	view →
KIRC	All	All	+0.430	<.001	4	view →
CHOL	All	All	+0.830	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ITGA10–LUSC

Open the LUSC breakdown →