ITGA10

Across TCGA pan-cancer cohorts, ITGA10 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated ITGA10 data layer compared with 8 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ITGA10 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGA10 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

KIRP, UVM, and UCEC are the cancer types where ITGA10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.448	1.000	<.001	92	view →
UVM	OS	Median	III,IV	0.630	0.968	<.001	67	view →
UCEC	OS	Quartile	IV	0.737	0.246	.001	62	view →
MESO	OS	Quartile	II,III,IV	0.465	0.713	.005	62	view →
LGG	OS	Median	All	0.858	0.931	<.001	45	view →
OV	OS	Median	III,IV	0.273	0.371	.006	38	view →
THCA	OS	Median	II,III,IV	0.759	0.960	.001	33	view →
SARC	DFS	Tertile	All	0.385	0.621	<.001	32	view →
STAD	DFS	Tertile	All	0.372	0.603	.019	29	view →
SKCM	DFS	Quartile	All	0.253	0.144	.005	25	view →
BRCA	OS	Median	All	0.978	0.946	.001	24	view →
PRAD	DFS	Tertile	All	0.831	0.924	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

ITGA10–KIRP (DFS)

Open the KIRP breakdown →