ITFG2

Across TCGA patient cohorts, ITFG2 mutation is significantly associated with the RNA expression of many other genes, with 987 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITFG2-associated genes across cancer lineages are RNA5SP389, LRRC57, and MEX3D. Each is linked with ITFG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITFG2-to-partner and partner-to-ITFG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP389 grouped by ITFG2-low versus ITFG2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITFG2→partner) and Y-score (partner→ITFG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP389 →	+0.102	+4.412	<.001	.006	3	2
UCEC	LRRC57 →	+0.696	+3.592	<.001	.001	3	2
UCEC	MEX3D →	+0.680	+3.191	.006	.009	3	2
UCEC	RNU6-4P →	+0.460	+2.109	.007	.008	3	2
HNSC	BNIP3P6 →	+0.059	+7.954	<.001	.008	3	2
UCEC	LINC01758 →	+0.166	+2.286	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 987 associations by consensus.

RNA5SP389 by ITFG2 expression — LUSC

Explore this box plot interactively →