ITCH-IT1

Across TCGA patient cohorts, ITCH-IT1 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,725 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ITCH-IT1-associated proteins across cancer lineages are SPIN1_S199, TNKS1BP1_S1158, and LRCH3_S352. Each is linked with ITCH-IT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITCH-IT1-to-partner and partner-to-ITCH-IT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITCH-IT1 versus SPIN1_S199 in LSCC, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ITCH-IT1→partner) and Y-score (partner→ITCH-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPIN1_S199 →	+0.424	+0.524	.008	.002	3	3
LSCC	TNKS1BP1_S1158 →	-0.749	-0.491	<.001	<.001	3	3
GBM	LRCH3_S352 →	-1.010	-0.716	<.001	<.001	3	3
CCRCC	PARP14 →	-0.278	-0.440	<.001	.002	3	3
GBM	RPRD1B →	+0.256	+0.452	.008	<.001	3	3
PDAC	PRPF4B_S294 →	+0.737	+0.382	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,725 associations by consensus.

ITCH-IT1 vs SPIN1_S199 — LSCC

Explore this scatter interactively →