ITCH-IT1

Across TCGA pan-cancer cohorts, ITCH-IT1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ITCH-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ITCH-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITCH-IT1 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

COAD, STAD, and BLCA are the cancer types where ITCH-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITCH-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.274	.005	6	view →
STAD	All	All	+0.590	.006	5	view →
BLCA	All	All	+0.338	.034	4	view →
LUAD	All	IV	−0.565	<.001	2	view →
LUSC	Male	All	+0.202	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ITCH-IT1–COAD

Open the COAD breakdown →