ITCH-IT1

Across TCGA pan-cancer cohorts, ITCH-IT1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated ITCH-IT1 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ITCH-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ITCH-IT1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

READ, KIRC, and COAD are the cancer types where ITCH-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Quartile	All	0.526	0.906	<.001	43	view →
KIRC	OS	Quartile	All	0.756	0.848	.004	36	view →
COAD	DFS	Median	All	0.688	0.822	.003	34	view →
UCEC	DFS	Quartile	II,III,IV	0.729	0.844	.004	32	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	27	view →
BRCA	OS	Quartile	III,IV	0.906	0.793	.011	24	view →
HNSC	DFS	Quartile	IV	0.735	0.530	.005	15	view →
LIHC	DFS	Tertile	II,III,IV	0.403	0.288	.028	15	view →
STAD	DFS	Quartile	All	0.476	0.613	.036	12	view →
SKCM	DFS	Quartile	All	0.278	0.181	.011	9	view →
THYM	DFS	Tertile	IV	0.407	1.000	.026	9	view →
ACC	OS	Quartile	II,III,IV	0.634	0.904	.025	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

ITCH-IT1–READ (OS)

Open the READ breakdown →