ITCH-IT1

Across TCGA patient cohorts, ITCH-IT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,764 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ITCH-IT1-associated GO terms across cancer lineages are Negative regulation of mRNA metabolic process, Alternative mRNA splicing, via spliceosome, and Epigenetic regulation of gene expression. Each is linked with ITCH-IT1 in more than 21 cancer types. Because this analysis shows association rather than direction, both ITCH-IT1-to-partner and partner-to-ITCH-IT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA metabolic process grouped by ITCH-IT1-low versus ITCH-IT1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITCH-IT1→partner) and Y-score (partner→ITCH-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of mRNA metabolic process →	+0.064	+0.758	<.001	<.001	3	22
STAD	Alternative mRNA splicing, via spliceosome →	+0.079	+0.790	<.001	<.001	3	22
STAD	Epigenetic regulation of gene expression →	+0.069	+0.805	<.001	<.001	3	22
STAD	Organelle disassembly →	+0.065	+0.727	<.001	<.001	3	21
STAD	Regulation of mRNA processing →	+0.080	+0.781	<.001	<.001	3	21
STAD	mRNA transport →	+0.076	+0.796	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,764 associations by consensus.

Negative regulation of mRNA metabolic process by ITCH-IT1 expression — STAD

Explore this box plot interactively →