ISY1-RAB43

Across TCGA patient cohorts, ISY1-RAB43 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,440 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ISY1-RAB43-associated GO terms across cancer lineages are Establishment of mitotic sister chromatid cohesion, Positive regulation of mRNA 3'-end processing, and Autophagosome organization. Each is linked with ISY1-RAB43 in more than 24 cancer types. Because this analysis shows association rather than direction, both ISY1-RAB43-to-partner and partner-to-ISY1-RAB43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of mitotic sister chromatid cohesion grouped by ISY1-RAB43-low versus ISY1-RAB43-high in SARC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISY1-RAB43→partner) and Y-score (partner→ISY1-RAB43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	Establishment of mitotic sister chromatid cohesion →	+0.054	+0.017	<.001	<.001	3	24
UCS	Positive regulation of mRNA 3'-end processing →	+0.078	+0.047	<.001	.002	1	25
SCLC	Autophagosome organization →	+0.046	+0.619	<.001	.001	3	22
SCLC	Regulation of macroautophagy →	+0.054	+0.646	<.001	<.001	3	22
SCLC	Negative regulation of macroautophagy →	+0.069	+0.589	.001	.001	2	23
SCLC	Regulation of autophagosome assembly →	+0.065	+0.602	<.001	.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,440 associations by consensus.

Establishment of mitotic sister chromatid cohesion by ISY1-RAB43 expression — SARC

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