ISY1-RAB43

Across TCGA pan-cancer cohorts, ISY1-RAB43 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ISY1-RAB43’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ISY1-RAB43 RNA is repressed in tumor relative to normal tissue. In most cancer types ISY1-RAB43 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KIRC, and KICH are the cancer types where ISY1-RAB43 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ISY1-RAB43 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	−0.023	<.001	8	view →
KIRC	All	All	+0.017	<.001	8	view →
KICH	All	II,III,IV	−0.027	<.001	7	view →
KIRP	Female	All	+0.034	.001	5	view →
HNSC	All	All	+0.022	.006	5	view →
BRCA	All	II,III,IV	−0.012	.005	4	view →
PAAD	Male	All	+0.025	.037	2	view →
CHOL	All	All	+0.025	.006	2	view →
THCA	All	II,III,IV	−0.013	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ISY1-RAB43–LUAD

Open the LUAD breakdown →