ISY1-RAB43

Across TCGA pan-cancer cohorts, ISY1-RAB43 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ISY1-RAB43 data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ISY1-RAB43 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ISY1-RAB43 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LGG show a favorable association.

HNSC, LGG, and CHOL are the cancer types where ISY1-RAB43 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.529	0.274	.001	54	view →
LGG	DFS	Tertile	All	0.892	0.767	<.001	31	view →
CHOL	OS	Tertile	All	0.057	0.841	<.001	21	view →
THYM	DFS	Tertile	II,III,IV	0.957	0.613	.008	19	view →
ESCA	OS	Tertile	IV	0.243	0.713	.024	18	view →
CESC	OS	Quartile	III,IV	0.084	0.641	.010	14	view →
BLCA	DFS	Quartile	II,III,IV	0.192	0.401	.010	13	view →
ACC	DFS	Tertile	All	0.404	0.717	.015	13	view →
READ	OS	Quartile	III,IV	1.000	0.346	.003	11	view →
UVM	DFS	Median	All	0.950	0.598	.024	9	view →
SKCM	DFS	Quartile	II,III,IV	0.830	0.642	.002	8	view →
BRCA	DFS	Median	II,III,IV	0.862	0.906	.028	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ISY1-RAB43–HNSC (DFS)

Open the HNSC breakdown →