ISY1-RAB43

Across TCGA patient cohorts, ISY1-RAB43 mutation is significantly associated with the RNA expression of many other genes, with 940 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISY1-RAB43-associated genes across cancer lineages are RNA5SP355, SNORD90, and TPT1P3. Each is linked with ISY1-RAB43 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISY1-RAB43-to-partner and partner-to-ISY1-RAB43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP355 grouped by ISY1-RAB43-low versus ISY1-RAB43-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISY1-RAB43→partner) and Y-score (partner→ISY1-RAB43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP355 →	+0.143	+4.247	<.001	.007	3	2
UCEC	SNORD90 →	+0.284	+2.769	.004	.002	3	2
SKCM	TPT1P3 →	+0.224	+3.949	<.001	.002	3	2
UCEC	RNU6-380P →	+0.170	+4.148	<.001	.006	3	2
BLCA	RNU6-225P →	+0.352	+7.640	<.001	.009	3	1
SKCM	SEPTIN7P12 →	+0.094	+2.866	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 940 associations by consensus.

RNA5SP355 by ISY1-RAB43 expression — CESC

Explore this box plot interactively →