ISL2

Across TCGA patient cohorts, ISL2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,624 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ISL2-associated genes across cancer lineages are PIAS4, TNPO2, and CCRL2. Each is linked with ISL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISL2-to-partner and partner-to-ISL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISL2 versus PIAS4 in LSCC, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISL2→partner) and Y-score (partner→ISL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PIAS4 →	+0.790	+0.752	.005	.008	3	2
LSCC	TNPO2 →	+1.178	+0.851	.006	.004	3	2
GBM	CCRL2 →	-1.788	-1.456	<.001	.006	3	2
LSCC	ILF3 →	+0.897	+0.714	.008	.006	3	2
GBM	RILPL2 →	-0.778	-1.209	<.001	.004	3	2
GBM	NLRP3 →	-2.313	-1.439	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,624 associations by consensus.

ISL2 vs PIAS4 — LSCC

Explore this scatter interactively →