ISL2

Across TCGA pan-cancer cohorts, ISL2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ISL2’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ISL2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ISL2 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

BLCA, LUSC, and LUAD are the cancer types where ISL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ISL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	+1.707	<.001	9	view →
LUSC	All	II,III,IV	+0.942	<.001	7	view →
LUAD	All	All	+0.355	<.001	7	view →
UCEC	All	All	+0.636	.003	6	view →
LIHC	All	II,III,IV	+0.437	<.001	6	view →
KIRC	Male	All	+0.117	<.001	5	view →
BRCA	Female	All	+0.160	<.001	4	view →
CHOL	All	All	+0.433	<.001	3	view →
ESCA	All	All	+1.058	.005	2	view →
PRAD	All	All	−0.834	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ISL2–BLCA

Open the BLCA breakdown →