ISL2

Across TCGA patient cohorts, ISL2 mutation is significantly associated with the RNA expression of many other genes, with 431 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISL2-associated genes across cancer lineages are TRBV8-1, TRBV21OR9-2, and IGHD6-13. Each is linked with ISL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISL2-to-partner and partner-to-ISL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRBV8-1 grouped by ISL2-low versus ISL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISL2→partner) and Y-score (partner→ISL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRBV8-1 →	+0.241	+3.039	<.001	.001	3	2
CESC	TRBV21OR9-2 →	+0.087	+5.252	<.001	.002	3	1
CESC	IGHD6-13 →	+1.107	+3.816	.003	.007	3	1
CESC	RNA5SP332 →	+0.246	+5.579	<.001	.001	3	1
CESC	CPLX3 →	+0.013	+4.757	<.001	.004	3	1
CESC	YY1P2 →	+0.028	+5.252	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 431 associations by consensus.

TRBV8-1 by ISL2 expression — UCEC

Explore this box plot interactively →