ISL2

Across TCGA cell cohorts, ISL2 RNA expression is significantly associated with the RNA expression of many other genes, with 7,945 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ISL2-associated genes across cancer lineages are CBX8, HMBOX1, and CHERP. Each is linked with ISL2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ISL2-to-partner and partner-to-ISL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISL2 versus CBX8 in BONE, with a Pearson correlation of 0.56.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISL2→partner) and Y-score (partner→ISL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CBX8 →	+1.144	+1.414	.001	<.001	2	8
BLOOD_Lymphoma	HMBOX1 →	+0.863	+1.047	<.001	<.001	3	7
BLOOD_Lymphoma	CHERP →	+0.933	+1.242	<.001	<.001	3	7
BLOOD_Lymphoma	DHX38 →	+0.791	+0.955	<.001	<.001	3	6
BONE	SNRNP200 →	+0.874	+1.202	<.001	<.001	3	6
BLOOD_Lymphoma	LONP1 →	+0.943	+1.015	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,945 associations by consensus.

ISL2 vs CBX8 — BONE

Explore this scatter interactively →