ISL1

Across TCGA patient cohorts, ISL1 mutation is significantly associated with the RNA expression of many other genes, with 4,556 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISL1-associated genes across cancer lineages are XIRP1, RN7SL248P, and CCNB1IP1P2. Each is linked with ISL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ISL1-to-partner and partner-to-ISL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XIRP1 grouped by ISL1-low versus ISL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISL1→partner) and Y-score (partner→ISL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XIRP1 →	+0.122	+1.912	.005	.004	3	3
BRCA	RN7SL248P →	+0.133	+5.786	<.001	.001	3	2
LGG	CCNB1IP1P2 →	+0.054	+4.936	<.001	.005	3	2
SKCM	GOLGA2P6 →	+0.013	+4.804	<.001	<.001	3	2
BRCA	RNA5SP45 →	+0.359	+5.324	<.001	.003	3	2
BLCA	SNRPD2P2 →	+0.189	+4.376	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,556 associations by consensus.

XIRP1 by ISL1 expression — UCEC

Explore this box plot interactively →