ISCUP1

Q-omics provides the consensus-scored ISCUP1 profile across patient tissues and cancer cell-line models. ISCUP1 expression is associated with patient survival in 5 of 34 cancer types, with the highest sampling consensus in LGG. Additionally, ISCUP1 RNA expression shows 5,447 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight LGG, and STAD as cancer lineages where ISCUP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Survival associations

This table summarizes ISCUP1 survival associations across molecular data types. ISCUP1 RNA expression shows survival associations in the most cancer types (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

ISCUP1 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	5	LGG (54)	view →

This table ranks reproducible ISCUP1 RNA expression–survival associations across cancer types. High ISCUP1 expression shows unfavorable associations in LGG, KIRP, DLBC and LAML, but favorable associations in SKCM. The LGG Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for ISCUP1 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Tertile	All	0.252	0.815	<.001	54	view →
KIRP	DFS	Tertile	II,III,IV	0.122	0.626	.032	18	view →
DLBC	OS	Tertile	II,III,IV	0.118	0.802	.025	18	view →
LAML	DFS	Tertile	All	0.112	0.590	.006	18	view →
SKCM	OS	Tertile	All	0.871	0.309	.031	9	view →

Pink = unfavorable, green = favorable. all 5 lineages →

ISCUP1-LGG (OS)

Explore this curve interactively →