ISCUP1

Across TCGA pan-cancer cohorts, ISCUP1 RNA is linked to patient survival in 5 of 34 cancer types, making it the most broadly survival-associated ISCUP1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher ISCUP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ISCUP1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LGG, DLBC, and KIRP are the cancer types where ISCUP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Tertile	All	0.252	0.815	<.001	54	view →
DLBC	OS	Tertile	II,III,IV	0.118	0.802	.025	18	view →
KIRP	DFS	Tertile	II,III,IV	0.122	0.626	.032	18	view →
LAML	DFS	Tertile	All	0.112	0.590	.006	18	view →
SKCM	OS	Tertile	All	0.871	0.309	.031	9	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ISCUP1–LGG (OS)

Open the LGG breakdown →