ISCA1P3

Across TCGA patient cohorts, ISCA1P3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,227 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ISCA1P3-associated GO terms across cancer lineages are DNA integrity checkpoint signaling, Mitotic recombination, and Protein-DNA complex assembly. Each is linked with ISCA1P3 in more than 5 cancer types. Because this analysis shows association rather than direction, both ISCA1P3-to-partner and partner-to-ISCA1P3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA integrity checkpoint signaling grouped by ISCA1P3-low versus ISCA1P3-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISCA1P3→partner) and Y-score (partner→ISCA1P3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	DNA integrity checkpoint signaling →	+0.064	+0.040	<.001	.002	3	6
ESCA	Mitotic recombination →	+0.048	+0.057	<.001	.008	2	6
ESCA	Protein-DNA complex assembly →	+0.060	+0.041	<.001	.001	3	5
ESCA	DNA biosynthetic process →	+0.065	+0.049	<.001	.005	2	6
STAD	Ribosomal small subunit biogenesis →	+0.074	+0.061	<.001	.001	3	5
STAD	Positive regulation of proteolysis involved in protein catabolic process →	+0.067	+0.063	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,227 associations by consensus.

DNA integrity checkpoint signaling by ISCA1P3 expression — ESCA

Explore this box plot interactively →