ISCA1P3

Across TCGA pan-cancer cohorts, ISCA1P3 RNA is linked to patient survival in 6 of 34 cancer types, making it the most broadly survival-associated ISCA1P3 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ISCA1P3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ISCA1P3 expression acts as an unfavorable survival marker.

KIRP, BRCA, and LAML are the cancer types where ISCA1P3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.475	0.854	<.001	87	view →
BRCA	OS	Tertile	IV	0.106	0.791	<.001	36	view →
LAML	DFS	Tertile	All	0.182	0.590	.007	36	view →
HNSC	OS	Tertile	II,III,IV	0.512	0.763	.015	21	view →
THCA	OS	Tertile	All	0.918	0.979	.019	9	view →
LUAD	OS	Tertile	All	0.607	0.839	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ISCA1P3–KIRP (OS)

Open the KIRP breakdown →