ISCA1

Across TCGA patient cohorts, ISCA1 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISCA1-associated genes across cancer lineages are MIR6781, RNU6-1026P, and MIR181C. Each is linked with ISCA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISCA1-to-partner and partner-to-ISCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6781 grouped by ISCA1-low versus ISCA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISCA1→partner) and Y-score (partner→ISCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6781 →	+0.700	+2.780	.004	.008	3	1
UCEC	RNU6-1026P →	+0.398	+4.200	<.001	.001	3	1
UCEC	MIR181C →	+0.494	+3.048	<.001	.006	3	1
UCEC	MIR147A →	+0.294	+3.997	<.001	.009	3	1
UCEC	RNU6-1228P →	+0.213	+4.464	.003	.005	3	1
UCEC	OSTCP6 →	+0.465	+3.929	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

MIR6781 by ISCA1 expression — UCEC

Explore this box plot interactively →