ISCA1

Across TCGA pan-cancer cohorts, ISCA1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ISCA1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ISCA1 RNA is repressed in tumor relative to normal tissue. In most cancer types ISCA1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, HNSC, and KIRC are the cancer types where ISCA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ISCA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−1.376	<.001	11	view →
HNSC	Male	IV	+0.908	<.001	11	view →
KIRC	All	III,IV	−0.349	<.001	8	view →
LIHC	All	All	+0.331	<.001	8	view →
KIRP	Male	All	−0.733	<.001	6	view →
LUAD	Female	III,IV	−0.704	.003	6	view →
BRCA	Female	All	−0.309	<.001	6	view →
KICH	Male	All	−1.023	<.001	5	view →
CHOL	All	All	+0.707	.024	4	view →
UCEC	All	All	−0.805	<.001	2	view →
COAD	Female	All	−0.484	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ISCA1–THCA

Open the THCA breakdown →