Across TCGA patient cohorts, IRF1-AS1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF1-AS1-associated genes across cancer lineages are ATF4P2, BCRP6, and AQP7P4. Each is linked with IRF1-AS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF1-AS1-to-partner and partner-to-IRF1-AS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF1-AS1→partner) and Y-score (partner→IRF1-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATF4P2 →	+0.088	+4.184	<.001	.003	3	1
UCEC	BCRP6 →	+0.162	+3.661	<.001	.009	3	1
UCEC	AQP7P4 →	+0.096	+4.442	<.001	.007	3	1
UCEC	MIR6859-4 →	+1.310	+4.863	<.001	<.001	3	1
UCEC	AQP7P3 →	+0.093	+4.997	<.001	.003	3	1
UCEC	LINC01896 →	+0.856	+4.078	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

IRF1-AS1 survival (RNA) · tumor vs normal (RNA) · all IRF1-AS1 data types