Across TCGA pan-cancer cohorts, IRF1-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IRF1-AS1 data layer compared with 2 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IRF1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IRF1-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and MESO show a favorable association.

SKCM, MESO, and HNSC are the cancer types where IRF1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.417	0.263	<.001	139	view →
MESO	OS	Tertile	All	0.563	0.256	<.001	108	view →
HNSC	DFS	Tertile	All	0.769	0.638	.001	95	view →
BLCA	OS	Median	IV	0.683	0.490	.002	66	view →
UVM	DFS	Tertile	All	0.351	0.737	.008	53	view →
KICH	DFS	Median	II,III,IV	0.676	0.964	.003	41	view →
LGG	DFS	Tertile	All	0.680	0.831	<.001	33	view →
BRCA	OS	Tertile	III,IV	0.958	0.846	.002	24	view →
SARC	OS	Tertile	All	0.831	0.607	<.001	24	view →
THYM	DFS	Tertile	All	0.458	0.892	.005	22	view →
READ	DFS	Median	III,IV	0.882	0.593	.004	21	view →
PRAD	DFS	Median	All	0.710	0.824	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

Exploration

Same gene, other analysis: IRF1-AS1 tumor-vs-normal RNA expression · all IRF1-AS1 data types