Across TCGA patient cohorts, IQGAP3 mutation is significantly associated with the RNA expression of many other genes, with 4,215 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQGAP3-associated genes across cancer lineages are MRPL57, CKS2, and RNU6-17P. Each is linked with IQGAP3 in more than 3 cancer types. Because this analysis shows association rather than direction, both IQGAP3-to-partner and partner-to-IQGAP3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQGAP3→partner) and Y-score (partner→IQGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL57 →	+0.218	+2.606	.002	<.001	3	4
UCEC	CKS2 →	+0.677	+2.115	<.001	<.001	3	4
GBM	RNU6-17P →	+0.420	+3.754	<.001	.007	3	3
LUSC	DOC2B →	-0.884	-3.567	.008	.002	3	3
UCEC	TAF9 →	+0.580	+3.136	<.001	<.001	3	3
UCEC	RN7SL248P →	+0.032	+2.263	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,215 associations by consensus.

Exploration

IQGAP3 survival (RNA) · tumor vs normal (RNA) · all IQGAP3 data types