Across TCGA pan-cancer cohorts, IQGAP3 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of IQGAP3’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where IQGAP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IQGAP3 is over-expressed in tumor.
BLCA, COAD, and HNSC are the cancer types where IQGAP3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IQGAP3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.