IQCH

Across TCGA patient cohorts, IQCH RNA expression is significantly associated with the protein abundance of many other proteins, with 13,214 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IQCH-associated proteins across cancer lineages are SIN3A, KHDRBS1_S58, and IFT74. Each is linked with IQCH in more than 4 cancer types. Because this analysis shows association rather than direction, both IQCH-to-partner and partner-to-IQCH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQCH versus SIN3A in LSCC, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCH→partner) and Y-score (partner→IQCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SIN3A →	+0.288	+0.601	<.001	<.001	3	5
GBM	KHDRBS1_S58 →	+0.383	+0.419	<.001	<.001	3	5
GBM	IFT74 →	+0.421	+0.458	.002	.001	3	5
HNSC	ZNF638 →	+0.306	+0.626	<.001	<.001	3	4
BRCA	ZNF706 →	-0.435	-0.675	<.001	<.001	3	4
LSCC	RCN2 →	+0.481	+0.447	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,214 associations by consensus.

IQCH vs SIN3A — LSCC

Explore this scatter interactively →