IQCH

Across TCGA pan-cancer cohorts, IQCH RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated IQCH data layer compared with 6 for mutation status.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher IQCH RNA is associated with better overall survival. In most high-consensus cancer types, elevated IQCH expression acts as an unfavorable survival marker, although some lineages such as READ and UVM show a favorable association.

READ, UVM, and UCEC are the cancer types where IQCH RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	III,IV	0.724	0.268	.001	70	view →
UVM	DFS	Quartile	II,III,IV	0.906	0.518	.002	63	view →
UCEC	OS	Median	All	0.959	0.893	<.001	60	view →
SCLC	OS	Tertile	All	0.597	0.275	.001	59	view →
LGG	DFS	Median	All	0.636	0.845	<.001	54	view →
KIRC	DFS	Tertile	All	0.705	0.521	.001	37	view →
BRCA	OS	Tertile	III,IV	0.910	0.746	.002	35	view →
ACC	DFS	Median	All	0.290	0.619	.003	27	view →
KIRP	DFS	Quartile	All	1.000	0.739	.011	12	view →
THCA	DFS	Median	All	0.887	0.788	.021	12	view →
LUAD	OS	Median	II,III,IV	0.732	0.620	.036	8	view →
CHOL	DFS	Tertile	All	0.580	0.257	.005	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

IQCH–READ (OS)

Open the READ breakdown →