IQCC

Across TCGA patient cohorts, IQCC mutation is significantly associated with the RNA expression of many other genes, with 706 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCC-associated genes across cancer lineages are RNU6-1246P, RNU6-222P, and LINC01656. Each is linked with IQCC in more than 2 cancer types. Because this analysis shows association rather than direction, both IQCC-to-partner and partner-to-IQCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1246P grouped by IQCC-low versus IQCC-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCC→partner) and Y-score (partner→IQCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1246P →	+1.377	+7.741	<.001	.009	3	3
CESC	RNU6-222P →	+0.392	+4.551	.001	.004	3	2
CESC	LINC01656 →	+0.161	+4.234	<.001	.008	3	2
HNSC	RN7SL794P →	+0.252	+4.270	.003	.008	3	2
SKCM	RN7SL524P →	+0.166	+3.801	<.001	.007	3	2
HNSC	RN7SL306P →	+0.212	+4.245	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 706 associations by consensus.

RNU6-1246P by IQCC expression — COAD

Explore this box plot interactively →