IQCC

Across TCGA cell cohorts, IQCC RNA expression is significantly associated with the go_rna of many other GO terms, with 3,933 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQCC-associated GO terms across cancer lineages are Centrosome cycle, Spindle organization, and Microtubule cytoskeleton organization involved in mitosis. Each is linked with IQCC in more than 16 cancer types. Because this analysis shows association rather than direction, both IQCC-to-partner and partner-to-IQCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome cycle grouped by IQCC-low versus IQCC-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCC→partner) and Y-score (partner→IQCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Centrosome cycle →	+0.103	+0.969	<.001	<.001	3	17
BONE	Spindle organization →	+0.106	+0.808	.004	.006	2	17
BONE	Microtubule cytoskeleton organization involved in mitosis →	+0.126	+0.937	.002	<.001	3	16
LARGE_INTESTINE	Microtubule organizing center organization →	+0.086	+0.655	<.001	<.001	3	15
BONE	Double-strand break repair →	+0.108	+0.996	<.001	<.001	3	15
SOFT_TISSUE	Positive regulation of cell cycle process →	+0.093	+0.801	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,933 associations by consensus.

Centrosome cycle by IQCC expression — BONE

Explore this box plot interactively →