IQCC

Across TCGA cell cohorts, IQCC mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQCC-associated genes across cancer lineages are H2BW2, PRAMEF19, and GHRHR. Each is linked with IQCC in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCC-to-partner and partner-to-IQCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW2 grouped by IQCC-low versus IQCC-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCC→partner) and Y-score (partner→IQCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BW2 →	+0.049	+4.930	<.001	.008	3	1
BREAST	PRAMEF19 →	+0.019	+5.169	<.001	.005	3	1
BLOOD_Leukemia	GHRHR →	+0.407	+4.705	<.001	.003	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.470	+3.772	<.001	.003	3	1
LARGE_INTESTINE	TMSB4Y →	+1.379	+3.556	<.001	.007	3	1
LARGE_INTESTINE	OR2V2 →	+0.010	+2.925	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

H2BW2 by IQCC expression — SOFT_TISSUE

Explore this box plot interactively →