INVS

Across TCGA patient cohorts, INVS mutation is significantly associated with the RNA expression of many other genes, with 4,400 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INVS-associated genes across cancer lineages are RNA5SP418, TLCD3A, and FCGR1A. Each is linked with INVS in more than 2 cancer types. Because this analysis shows association rather than direction, both INVS-to-partner and partner-to-INVS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP418 grouped by INVS-low versus INVS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INVS→partner) and Y-score (partner→INVS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP418 →	+0.683	+2.104	<.001	<.001	3	3
UCEC	TLCD3A →	+0.498	+3.098	.002	<.001	3	3
COAD	FCGR1A →	+0.958	+3.223	<.001	.009	3	2
COAD	CXXC1 →	+0.605	+3.223	.001	.009	3	2
COAD	KIR3DL1 →	+0.335	+2.915	<.001	.007	3	2
COAD	RCC1 →	+0.736	+3.223	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,400 associations by consensus.

RNA5SP418 by INVS expression — UCEC

Explore this box plot interactively →