INVS

Across TCGA pan-cancer cohorts, INVS RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of INVS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where INVS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types INVS is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where INVS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INVS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.965	<.001	12	view →
THCA	Male	III,IV	−0.927	<.001	10	view →
COAD	Male	All	+0.483	<.001	9	view →
KICH	Female	All	−1.201	<.001	7	view →
LUSC	All	All	+0.377	<.001	5	view →
CHOL	All	II,III,IV	+1.210	.022	4	view →
READ	All	All	+0.435	.006	4	view →
BRCA	All	All	−0.252	<.001	4	view →
BLCA	Female	All	+0.576	.018	3	view →
STAD	Male	II,III,IV	+0.575	.026	3	view →
KIRP	Male	All	−0.362	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

INVS–HNSC

Open the HNSC breakdown →