INVS

Across TCGA cell cohorts, INVS mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INVS-associated genes across cancer lineages are H4C13, KRTAP5-4, and RNASE9. Each is linked with INVS in more than 1 cancer types. Because this analysis shows association rather than direction, both INVS-to-partner and partner-to-INVS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H4C13 grouped by INVS-low versus INVS-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INVS→partner) and Y-score (partner→INVS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	H4C13 →	+0.586	+4.121	<.001	.006	3	2
SOFT_TISSUE	KRTAP5-4 →	+0.024	+4.369	<.001	.008	3	2
LUNG_NSCLC_LUAD	RNASE9 →	+0.015	+4.472	<.001	.001	3	2
LARGE_INTESTINE	ACSM6 →	+0.013	+2.321	.003	.004	3	2
OVARY	SLC22A25 →	+0.289	+5.196	<.001	.005	3	2
BLOOD_Myeloma	PABPC1L2B →	+0.006	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

H4C13 by INVS expression — KIDNEY

Explore this box plot interactively →