INSL6

Across TCGA patient cohorts, INSL6 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSL6-associated genes across cancer lineages are PDCD4, Shc_pY317, and EGFR_pY1068. Each is linked with INSL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both INSL6-to-partner and partner-to-INSL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by INSL6-low versus INSL6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSL6→partner) and Y-score (partner→INSL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.812	-2.807	<.001	.003	3	2
UCEC	Shc_pY317 →	-0.207	-3.169	.001	.018	3	2
UCEC	EGFR_pY1068 →	-0.258	-2.807	.018	.003	3	1
UCEC	Gab2 →	+0.496	+3.000	.001	.036	3	1
UCEC	JNK2 →	+0.213	+3.026	.014	.018	3	1
UCEC	mTOR_pS2448 →	-0.143	-2.115	.027	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PDCD4 by INSL6 expression — UCEC

Explore this box plot interactively →