INSL6

Across TCGA pan-cancer cohorts, INSL6 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated INSL6 data layer compared with 2 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher INSL6 RNA is associated with better overall survival. In most high-consensus cancer types, elevated INSL6 expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

BLCA, BRCA, and MESO are the cancer types where INSL6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	0.752	0.662	.005	63	view →
BRCA	OS	Median	All	0.949	0.900	.001	56	view →
MESO	OS	Tertile	III,IV	0.903	0.354	.002	53	view →
THYM	DFS	Quartile	All	0.473	1.000	.001	35	view →
READ	DFS	Tertile	IV	0.155	0.668	<.001	27	view →
KIRC	DFS	Median	II,III,IV	0.742	0.819	.011	24	view →
CESC	OS	Median	All	0.867	0.723	.001	24	view →
LGG	DFS	Tertile	All	0.755	0.859	.001	21	view →
DLBC	DFS	Tertile	All	0.570	1.000	.028	16	view →
ESCA	OS	Quartile	All	0.635	0.831	.007	16	view →
UVM	OS	Quartile	All	0.398	0.761	.019	13	view →
ACC	OS	Tertile	IV	1.000	0.385	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

INSL6–BLCA (OS)

Open the BLCA breakdown →