INSL6

Across TCGA pan-cancer cohorts, INSL6 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of INSL6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where INSL6 RNA is repressed in tumor relative to normal tissue. In most cancer types INSL6 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and COAD are the cancer types where INSL6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INSL6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.323	<.001	8	view →
KIRC	Male	II,III,IV	−0.135	<.001	8	view →
COAD	All	All	−0.061	<.001	6	view →
LUSC	Male	All	−0.080	.003	4	view →
PRAD	All	All	+0.217	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

INSL6–KICH

Open the KICH breakdown →