INSL6

Across TCGA cell cohorts, INSL6 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,320 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible INSL6-associated GO terms across cancer lineages are Negative regulation of cilium assembly, Negative regulation of mRNA processing, and Negative regulation of mRNA splicing, via spliceosome. Each is linked with INSL6 in more than 7 cancer types. Because this analysis shows association rather than direction, both INSL6-to-partner and partner-to-INSL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cilium assembly grouped by INSL6-low versus INSL6-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INSL6→partner) and Y-score (partner→INSL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Negative regulation of cilium assembly →	+0.061	+0.099	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA processing →	+0.075	+0.086	<.001	.006	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA splicing, via spliceosome →	+0.076	+0.083	.001	.008	3	7
SOFT_TISSUE	Microtubule nucleation →	+0.076	+0.050	.001	<.001	3	6
BLOOD_Leukemia	Regulation of myoblast fusion →	+0.060	+0.193	<.001	<.001	3	6
BLOOD_Leukemia	Negative regulation of myoblast fusion →	+0.070	+0.194	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,320 associations by consensus.

Negative regulation of cilium assembly by INSL6 expression — CNS

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