INSIG2

Across TCGA patient cohorts, INSIG2 mutation is significantly associated with the RNA expression of many other genes, with 2,657 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INSIG2-associated genes across cancer lineages are RNU7-50P, RN7SL248P, and RPL32P23. Each is linked with INSIG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both INSIG2-to-partner and partner-to-INSIG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-50P grouped by INSIG2-low versus INSIG2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INSIG2→partner) and Y-score (partner→INSIG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU7-50P →	+1.300	+5.212	<.001	.007	3	3
UCEC	RN7SL248P →	+0.046	+2.783	<.001	.009	3	2
BRCA	RPL32P23 →	+0.098	+4.986	<.001	.003	3	2
BRCA	H2BP8 →	+0.120	+5.365	<.001	.002	3	2
UCEC	RNU7-29P →	+0.132	+2.783	<.001	.009	3	2
LUSC	RNA5SP420 →	+0.637	+4.724	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,657 associations by consensus.

RNU7-50P by INSIG2 expression — COAD

Explore this box plot interactively →