INS-IGF2

Across TCGA patient cohorts, INS-IGF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,305 significant associations in total. STAD shows the largest number of these associations.

The most reproducible INS-IGF2-associated GO terms across cancer lineages are Positive regulation of lipid metabolic process, Heart morphogenesis, and Ventricular septum morphogenesis. Each is linked with INS-IGF2 in more than 8 cancer types. Because this analysis shows association rather than direction, both INS-IGF2-to-partner and partner-to-INS-IGF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of lipid metabolic process grouped by INS-IGF2-low versus INS-IGF2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (INS-IGF2→partner) and Y-score (partner→INS-IGF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of lipid metabolic process →	+0.042	+0.015	<.001	<.001	3	9
STAD	Heart morphogenesis →	+0.052	+0.022	<.001	<.001	3	9
STAD	Ventricular septum morphogenesis →	+0.059	+0.013	<.001	<.001	3	9
STAD	Regulation of cell-substrate junction organization →	+0.078	+0.012	<.001	<.001	3	9
STAD	Regulation of protein serine/threonine kinase activity →	+0.054	+0.021	<.001	<.001	3	9
STAD	Artery development →	+0.063	+0.014	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,305 associations by consensus.

Positive regulation of lipid metabolic process by INS-IGF2 expression — STAD

Explore this box plot interactively →