INS-IGF2

Across TCGA pan-cancer cohorts, INS-IGF2 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated INS-IGF2 data layer compared with 1 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher INS-IGF2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated INS-IGF2 expression acts as an unfavorable survival marker, although some lineages such as LIHC and UCS show a favorable association.

KIRC, MESO, and OV are the cancer types where INS-IGF2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	II,III,IV	0.145	0.513	.005	78	view →
MESO	OS	Tertile	II,III,IV	0.298	0.594	.003	63	view →
OV	DFS	Quartile	II,III,IV	0.468	0.564	.008	54	view →
LUSC	OS	Tertile	II,III,IV	0.043	0.781	<.001	42	view →
LIHC	OS	Quartile	All	0.894	0.740	.001	36	view →
UCS	DFS	Median	III,IV	0.610	0.301	.024	16	view →
LGG	OS	Quartile	All	0.815	0.991	<.001	16	view →
UCEC	OS	Tertile	All	0.313	0.702	.014	12	view →
KIRP	OS	Tertile	All	0.148	0.708	.001	12	view →
HNSC	DFS	Tertile	IV	0.319	0.551	.041	9	view →
SKCM	DFS	Tertile	All	0.998	0.716	.042	6	view →
PAAD	DFS	Median	III,IV	0.893	0.470	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

INS-IGF2–KIRC (DFS)

Open the KIRC breakdown →