INPP5K

Across TCGA cell cohorts, INPP5K mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INPP5K-associated genes across cancer lineages are CCDC54, ACER1, and OR2C1. Each is linked with INPP5K in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP5K-to-partner and partner-to-INPP5K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC54 grouped by INPP5K-low versus INPP5K-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5K→partner) and Y-score (partner→INPP5K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC54 →	+0.170	+3.736	<.001	.004	3	1
LARGE_INTESTINE	ACER1 →	+0.083	+4.145	.003	.001	3	1
LARGE_INTESTINE	OR2C1 →	+0.101	+3.725	.002	.008	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	IQCF6 →	+0.228	+3.882	<.001	.001	3	1
LUNG_NSCLC_LUAD	TCP10L2 →	+0.036	+4.887	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CCDC54 by INPP5K expression — LARGE_INTESTINE

Explore this box plot interactively →