INPP5K

Across TCGA pan-cancer cohorts, INPP5K RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of INPP5K’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where INPP5K RNA is repressed in tumor relative to normal tissue. In most cancer types INPP5K is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and HNSC are the cancer types where INPP5K tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INPP5K RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.343	<.001	11	view →
LUAD	Female	III,IV	−1.316	<.001	11	view →
HNSC	All	III,IV	+0.373	<.001	10	view →
LUSC	All	III,IV	−1.360	<.001	9	view →
READ	All	All	−0.541	.001	7	view →
COAD	Female	All	−0.415	<.001	7	view →
THCA	Female	All	+0.395	<.001	7	view →
LIHC	Female	II,III,IV	+0.915	<.001	6	view →
BRCA	All	All	−0.647	<.001	6	view →
CHOL	Female	All	+1.986	<.001	5	view →
KIRC	All	All	+0.288	<.001	3	view →
UCEC	All	All	−0.379	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

INPP5K–KICH

Open the KICH breakdown →