Across TCGA patient cohorts, INPP5J mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INPP5J-associated genes across cancer lineages are A-Raf_pS299, Notch1, and TFRC. Each is linked with INPP5J in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP5J-to-partner and partner-to-INPP5J results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5J→partner) and Y-score (partner→INPP5J) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.157	-2.584	<.001	.010	3	2
UCEC	Notch1 →	+0.165	+2.424	<.001	.001	3	2
UCEC	TFRC →	+0.468	+2.070	.011	.001	3	2
UCEC	ATM →	-0.443	-1.736	.004	.007	3	2
UCEC	14-3-3_beta →	-0.111	-2.295	.001	.005	3	1
UCEC	eEF2 →	+0.314	+1.440	.011	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

INPP5J survival (RNA) · tumor vs normal (RNA) · all INPP5J data types