Across TCGA pan-cancer cohorts, INPP5J RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated INPP5J data layer compared with 10 for mutation status and 3 for mass-spec protein.
The strongest signal is observed in uveal melanoma (UVM), where higher INPP5J RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated INPP5J expression acts as an unfavorable survival marker, although some lineages such as LUAD and READ show a favorable association.
UVM, LUAD, and LIHC are the cancer types where INPP5J RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.