Across TCGA cell cohorts, INPP5J mutation is significantly associated with the RNA expression of many other genes, with 605 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INPP5J-associated genes across cancer lineages are FBXW10, TRARG1, and EIF3L. Each is linked with INPP5J in more than 1 cancer types. Because this analysis shows association rather than direction, both INPP5J-to-partner and partner-to-INPP5J results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP5J→partner) and Y-score (partner→INPP5J) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW10 →	+0.200	+3.714	<.001	.001	3	2
LARGE_INTESTINE	TRARG1 →	+0.012	+2.345	.009	.007	3	2
LARGE_INTESTINE	EIF3L →	+0.512	+3.087	.003	.006	3	1
LARGE_INTESTINE	CCDC134 →	+0.742	+3.502	.002	.001	3	1
LARGE_INTESTINE	CBY1 →	+0.791	+3.588	<.001	<.001	3	1
LARGE_INTESTINE	DDHD1 →	+0.894	+3.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 605 associations by consensus.

Exploration

INPP5J survival (RNA) · tumor vs normal (RNA) · all INPP5J data types