INPP4B

Across TCGA cell cohorts, INPP4B mutation is significantly associated with the RNA expression of many other genes, with 260 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible INPP4B-associated genes across cancer lineages are FAM90A26, OR2T12, and SHISA6. Each is linked with INPP4B in more than 2 cancer types. Because this analysis shows association rather than direction, both INPP4B-to-partner and partner-to-INPP4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM90A26 grouped by INPP4B-low versus INPP4B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP4B→partner) and Y-score (partner→INPP4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FAM90A26 →	+0.014	+2.896	.002	.008	3	3
BLOOD_Myeloma	OR2T12 →	+0.060	+3.906	<.001	.009	3	2
LUNG_NSCLC_LUAD	SHISA6 →	+0.297	+3.043	<.001	.006	3	2
LUNG_NSCLC_LUAD	PRAMEF19 →	+0.008	+4.247	<.001	<.001	3	2
LARGE_INTESTINE	ELOA3CP →	+0.091	+2.827	.004	.002	3	2
BLOOD_Myeloma	C22orf31 →	+0.030	+4.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 260 associations by consensus.

FAM90A26 by INPP4B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →