INPP4B

Across TCGA pan-cancer cohorts, INPP4B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of INPP4B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where INPP4B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types INPP4B is over-expressed in tumor, although a few such as UCEC and THCA show the opposite, repressed pattern.

BLCA, HNSC, and UCEC are the cancer types where INPP4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INPP4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.936	.004	8	view →
HNSC	All	All	+0.667	<.001	7	view →
UCEC	All	All	−1.217	<.001	6	view →
LUAD	All	II,III,IV	+0.964	<.001	6	view →
CHOL	Male	All	+1.280	<.001	3	view →
THCA	Female	All	−0.419	<.001	3	view →
LUSC	All	All	−0.329	.015	3	view →
LIHC	All	All	+0.328	.002	3	view →
PAAD	All	All	+1.514	.006	2	view →
KIRP	Male	All	−0.644	<.001	2	view →
PRAD	All	All	+0.485	.007	2	view →
COAD	Female	All	−0.434	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

INPP4B–BLCA

Open the BLCA breakdown →