INPP4A

Across TCGA patient cohorts, INPP4A mutation is significantly associated with the RNA expression of many other genes, with 3,804 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible INPP4A-associated genes across cancer lineages are OR52N5, SKA1, and SMCR8. Each is linked with INPP4A in more than 2 cancer types. Because this analysis shows association rather than direction, both INPP4A-to-partner and partner-to-INPP4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52N5 grouped by INPP4A-low versus INPP4A-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INPP4A→partner) and Y-score (partner→INPP4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	OR52N5 →	+0.061	+5.189	<.001	.006	3	3
UCEC	SKA1 →	+0.559	+2.010	<.001	<.001	3	3
UCEC	SMCR8 →	+0.422	+1.330	.001	.007	3	3
UCEC	ZWINT →	+0.625	+1.807	<.001	<.001	3	3
UCEC	NUMB →	+0.271	+1.860	.004	<.001	3	3
UCEC	TMOD3 →	+0.506	+2.440	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,804 associations by consensus.

OR52N5 by INPP4A expression — SCLC

Explore this box plot interactively →