INPP4A

Across TCGA pan-cancer cohorts, INPP4A RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of INPP4A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where INPP4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types INPP4A is over-expressed in tumor.

HNSC, LIHC, and THCA are the cancer types where INPP4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INPP4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.121	<.001	12	view →
LIHC	Female	II,III,IV	+0.870	<.001	7	view →
THCA	Male	All	+0.627	<.001	7	view →
KIRC	All	All	+0.335	<.001	6	view →
CHOL	All	All	+1.961	<.001	5	view →
ESCA	All	All	+0.758	.015	2	view →
STAD	All	II,III,IV	+0.610	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

INPP4A–HNSC

Open the HNSC breakdown →